Research

Understanding the genetics of mesothelioma susceptibility and prognosis

Early cohort studies of people who lived and worked in the asbestos-mining town of Wittenoom in the north of WA have shown that mesothelioma clustered in different families from the town; most people who lived there did not develop mesothelioma. There is evidence of a substantial genetic involvement involved in who develops mesothelioma, but the specific genetic determinants remain largely unknown. The main objective of this research is to identify genetic variations that contribute to mesothelioma susceptibility, prognosis and response to therapy.

We are using data from the Genetic Understanding of Asbestos Related Diseases (GUARD) study to investigate the genes that contribute to mesothelioma susceptibility, prognosis and response to therapy.

Collaborators

This ongoing project is a collaborative effort between GOHaD,  The University of Western Australia, the Department of Respiratory Medicine at Sir Charles Gairdner Hospital (SCGH) and the National Centre for Asbestos Related Diseases (NCARD).

Funding

  • Royal Perth Hospital Medical Research Foundation [2016]. “Understanding the genetics of malignant mesothelioma susceptibility and prognosis”
    CIA Gemma Cadby, CIB Eric Moses, CIC Jenette Creaney, CID Sarah Ward, CIE Kevin Murray

Selected publications

  • Sneddon, S., J. S. Leon, I. M. Dick, Cadby, N. Olsen, F. Brims, R. J. Allcock, E. K. Moses, P. E. Melton, N. de Klerk, A. W. Musk, B. W. Robinson and J. Creaney (2015). “Absence of germline mutations in BAP1 in sporadic cases of malignant mesothelioma.” Gene 563(1): 103-105. [pubmed]
  • Cadby, G., S. Mukherjee, A. W. Musk, A. Reid, M. Garlepp, I. Dick, C. Robinson, J. Hui, G. Fiorito, S. Guarrera, J. Beilby, P. E. Melton, E. K. Moses, D. Ugolini, D. Mirabelli, S. Bonassi, C. Magnani, I. Dianzani, G. Matullo, B. Robinson, J. Creaney and L. J. Palmer (2013). “A genome-wide association study for malignant mesothelioma risk.” Lung Cancer 82(1): 1-8. [pubmed]
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